Risk factors and outcomes for carbapenem-resistant klebsiella pneumoniae in hematological patients

Background Prolonged hospitalization, prolonged neutropenia, and immunosuppressive treatments increase bloodstream infections in hematological patients. Identifying risk factors for carbapenem-resistant Klebsiella pneumonia (CRKP) infection will shed light on controlling the spread of CRKP. Our retrospective study aimed to determine clinical features, antimicrobial susceptibility, mortality patients who developed CRKP followed up cancer Izmir University Economics Haematology Department.
 Material Methods 19,170 blood-urine-sputum cultures were delivered from patients, 1,595 (8.31%) which presented growth. comprised 302 (1.57%) such growth cases. The included 72 with malignancy obtained during neutropenic fever period.
 Results mean age was 51 (18-75 years). Acute myeloid leukemia most common disease (n: 26, 36.11%). As antibiotic sensitivity CRKP, 44 (61.1%) colistin sensitive, 28 (38.9%) colistin-resistant, 47 (65.3%) tigecycline sensitive/medium sensitivity, 25 (34.7%) resistant, there no statistically significant difference between sensitivities survival.
 Conclusions Today, early detection colonization high-risk taking rectal culture, if patient presents or had bacteremia prior hospitalizations, initiation treatment antibiotics acting against NPF would significantly reduce mortality.